METATOOL OUTPUT Version 3.5 (28.03.2001) C:\METATOOL\META35~1.EXE INPUT FILE: EXAMPLE9.TXT INTERNAL METABOLITES: 67 REACTIONS: 34 9 external H2O 7 external ATP 6 external diphosphate 6 external ADP 5 int AMP 4 int phosphate 4 int 5-phospho-alpha-D-ribose_1-diphosphate 2 int 10-Formyltetrahydrofolate 2 int tetrahydrofolate 2 int D-ribose_5-phosphate 2 int RNAn 2 int RNAn+1 1 int Inosine_5`-phosphate 1 int NAD+ 1 int xanthosine_5`-phosphate 1 int NADH 1 int Ribonucleoside_diphosphate 1 int reduced_thioredoxin 1 int 2`-deoxyribonucleoside_diphosphate 1 int oxidized_thioredoxin 1 int NADPH 1 int guanosine_5`-phosphate 1 int NADP+ 1 int inosine_5`-phosphate 1 int 5`-phosphoribosylglycinamide 1 int 5`-phosphoribosyl-N-formylglycinamide 1 int 5`-phosphoribosyl-5-amino-4-imidazolecarboxamide 1 int 5`-phosphoribosyl-5-formamido-4-imidazolecarboxamide 1 int Purine_nucleoside 1 int purine 1 int alpha-D-ribose_1-phosphate 1 int 5-Phospho-beta-D-ribosylamine 1 int L-glutamate 1 int L-glutamine 1 int 5-Phospho-alpha-D-ribose_1-diphosphate 1 int xanthine 1 int (9-D-ribosylxanthine)-5`-phosphate 1 int Thymidine 1 int thymine 1 int 2-deoxy-D-ribose_1-phosphate 1 int Adenine 1 int Hypoxanthine 1 int IMP 1 int adenylylsulfate 1 int 3`-phosphoadenylylsulfate 1 int dAMP 1 int dADP 1 int nucleoside_diphosphate 1 int nucleoside_triphosphate 1 int GMP 1 int GDP 1 int GTP 1 int guanosine_3`-diphosphate_5`-triphosphate 1 int Nucleoside_triphosphate 1 int Deoxynucleoside_triphosphate 1 int DNAn 1 int DNAn+1 1 int a_nucleoside_diphosphate 1 int A_5`-ribonucleotide 1 int a_ribonucleoside 1 int Nucleoside_2`,3`-cyclic_phosphate 1 int nucleoside_3`-phosphate 1 int Nucleoside_3`,5`-cyclic_phosphate 1 int nucleoside_5`-phosphate 1 int dGTP 1 int deoxyguanosine 1 int triphosphate 1 int Inosine 1 int hypoxanthine 1 int D-ribose 1 int adenine 71 metabolites, 110 is the summarized frequency edges frequency of nodes 0 0 1 59 2 5 3 0 4 2 5 1 6 2 7 1 8 0 9 1 STOICHIOMETRIC MATRIX matrix dimension r67 x 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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 The following line indicates reversible (0) and irreversible reactions (1) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 rows and columns are sorted as declared in the inputfile NOT BALANCED INTERNAL METABOLITES Inosine_5`-phosphate NAD+ xanthosine_5`-phosphate NADH Ribonucleoside_diphosphate reduced_thioredoxin 2`-deoxyribonucleoside_diphosphate oxidized_thioredoxin NADPH guanosine_5`-phosphate NADP+ inosine_5`-phosphate 5`-phosphoribosylglycinamide 5`-phosphoribosyl-N-formylglycinamide 5`-phosphoribosyl-5-amino-4-imidazolecarboxamide 5`-phosphoribosyl-5-formamido-4-imidazolecarboxamide Purine_nucleoside purine alpha-D-ribose_1-phosphate 5-Phospho-beta-D-ribosylamine L-glutamate L-glutamine 5-Phospho-alpha-D-ribose_1-diphosphate xanthine (9-D-ribosylxanthine)-5`-phosphate Thymidine thymine 2-deoxy-D-ribose_1-phosphate Adenine Hypoxanthine IMP adenylylsulfate 3`-phosphoadenylylsulfate dAMP dADP nucleoside_diphosphate nucleoside_triphosphate GMP GDP GTP guanosine_3`-diphosphate_5`-triphosphate Nucleoside_triphosphate Deoxynucleoside_triphosphate DNAn DNAn+1 a_nucleoside_diphosphate A_5`-ribonucleotide a_ribonucleoside Nucleoside_2`,3`-cyclic_phosphate nucleoside_3`-phosphate Nucleoside_3`,5`-cyclic_phosphate nucleoside_5`-phosphate dGTP deoxyguanosine triphosphate Inosine hypoxanthine D-ribose adenine KERNEL matrix dimension r7 x c34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 34 reactions (columns) are sorted in the same order as in the ENZREV ENZIRREV section. enzymes 1: 2.1.2.2 irreversible 2: 2.1.2.3 irreversible 3: 2.4.2.1 irreversible 4: 2.4.2.4 irreversible 5: 2.7.1.25 irreversible 6: 2.7.6.1 irreversible 7: 3.1.3.5 irreversible overall reaction - not found - The remaining overall reactions perform no net transformation of external metabolites. SUBSETS OF REACTIONS matrix dimension r7 x c34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 34 reactions (columns) are sorted in the same order as in the ENZREV ENZIRREV section. enzymes 1: 2.1.2.2 irreversible 2: 2.1.2.3 irreversible 3: 2.4.2.1 irreversible 4: 2.4.2.4 irreversible 5: 2.7.1.25 irreversible 6: 2.7.6.1 irreversible 7: 3.1.3.5 irreversible overall reaction - not found - The remaining overall reactions perform no net transformation of external metabolites. REDUCED SYSTEM with 67 branch point metabolites in 7 reactions (columns) matrix dimension r0 x c7 The following line indicates reversible (0) and irreversible reactions (1) 1 1 1 1 1 1 1 -> Branch metabolites are : met cons built reactions -> No branch metabolites are : met cons built reactions Inosine_5`-phosphate 1 0 1 r NAD+ 1 0 1 r xanthosine_5`-phosphate 0 1 1 r NADH 0 1 1 r Ribonucleoside_diphosphate 1 0 1 i reduced_thioredoxin 1 0 1 i 2`-deoxyribonucleoside_diphosphate 0 1 1 i oxidized_thioredoxin 0 1 1 i NADPH 1 0 1 i guanosine_5`-phosphate 1 0 1 i NADP+ 0 1 1 i inosine_5`-phosphate 0 1 1 i 10-Formyltetrahydrofolate 2 0 2 rr 5`-phosphoribosylglycinamide 1 0 1 r tetrahydrofolate 0 2 2 rr 5`-phosphoribosyl-N-formylglycinamide 0 1 1 r 5`-phosphoribosyl-5-amino-4-imidazolecarboxamide 1 0 1 r 5`-phosphoribosyl-5-formamido-4-imidazolecarboxamide 0 1 1 r Purine_nucleoside 1 0 1 r phosphate 3 1 4 rrrr purine 0 1 1 r alpha-D-ribose_1-phosphate 0 1 1 r 5-Phospho-beta-D-ribosylamine 1 0 1 i L-glutamate 1 0 1 i L-glutamine 0 1 1 i 5-phospho-alpha-D-ribose_1-diphosphate 2 2 4 irrr 5-Phospho-alpha-D-ribose_1-diphosphate 1 0 1 r xanthine 1 0 1 r (9-D-ribosylxanthine)-5`-phosphate 0 1 1 r Thymidine 1 0 1 r thymine 0 1 1 r 2-deoxy-D-ribose_1-phosphate 0 1 1 r Adenine 1 0 1 r AMP 2 3 5 rrrii Hypoxanthine 1 0 1 r IMP 0 1 1 r adenylylsulfate 1 0 1 r 3`-phosphoadenylylsulfate 0 1 1 r dAMP 1 0 1 r dADP 0 1 1 r nucleoside_diphosphate 1 0 1 r nucleoside_triphosphate 0 1 1 r GMP 1 0 1 r GDP 0 1 1 r D-ribose_5-phosphate 1 1 2 ri GTP 1 0 1 i guanosine_3`-diphosphate_5`-triphosphate 0 1 1 i Nucleoside_triphosphate 1 0 1 r RNAn 1 1 2 rr RNAn+1 1 1 2 rr Deoxynucleoside_triphosphate 1 0 1 r DNAn 1 0 1 r DNAn+1 0 1 1 r a_nucleoside_diphosphate 0 1 1 r A_5`-ribonucleotide 1 0 1 r a_ribonucleoside 0 1 1 r Nucleoside_2`,3`-cyclic_phosphate 1 0 1 i nucleoside_3`-phosphate 0 1 1 i Nucleoside_3`,5`-cyclic_phosphate 1 0 1 i nucleoside_5`-phosphate 0 1 1 i dGTP 1 0 1 i deoxyguanosine 0 1 1 i triphosphate 0 1 1 i Inosine 1 0 1 i hypoxanthine 0 1 1 i D-ribose 0 1 1 i adenine 0 1 1 i CONVEX BASIS matrix dimension r7 x c34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 enzymes 1: 2.1.2.2 irreversible 2: 2.1.2.3 irreversible 3: 2.4.2.1 irreversible 4: 2.4.2.4 irreversible 5: 2.7.1.25 irreversible 6: 2.7.6.1 irreversible 7: 3.1.3.5 irreversible overall reaction - not found - The remaining overall reactions perform no net transformation of external metabolites. CONSERVATION RELATIONS matrix dimension r40 x c67 1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 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0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 -1 0 -1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 1 : Inosine_5`-phosphate + NAD+ = const 2 : Inosine_5`-phosphate + xanthosine_5`-phosphate = const 3 : Inosine_5`-phosphate + NADH = const 4 : Ribonucleoside_diphosphate + reduced_thioredoxin = const 5 : Ribonucleoside_diphosphate + 2`-deoxyribonucleoside_diphosphate = const 6 : Ribonucleoside_diphosphate + oxidized_thioredoxin = const 7 : NADPH + guanosine_5`-phosphate = const 8 : NADPH + NADP+ = const 9 : NADPH + inosine_5`-phosphate = const 10 : 10-Formyltetrahydrofolate + tetrahydrofolate = const 11 : 5`-phosphoribosylglycinamide + 5`-phosphoribosyl-N-formylglycinamide = const 12 : 10-Formyltetrahydrofolate + 5`-phosphoribosylglycinamide + 5`-phosphoribosyl-5-amino-4-imidazolecarboxamide = const 13 : 10-Formyltetrahydrofolate + 5`-phosphoribosylglycinamide + 5`-phosphoribosyl-5-formamido-4-imidazolecarboxamide = const 14 : Purine_nucleoside + purine = const 15 : Purine_nucleoside + alpha-D-ribose_1-phosphate = const 16 : 5-Phospho-beta-D-ribosylamine + L-glutamate = const 17 : 5-Phospho-beta-D-ribosylamine + L-glutamine = const 18 : 5-Phospho-alpha-D-ribose_1-diphosphate + xanthine = const 19 : 5-Phospho-alpha-D-ribose_1-diphosphate + (9-D-ribosylxanthine)-5`-phosphate = const 20 : Thymidine + thymine = const 21 : Thymidine + 2-deoxy-D-ribose_1-phosphate = const 22 : Hypoxanthine + IMP = const 23 : adenylylsulfate + 3`-phosphoadenylylsulfate = const 24 : dAMP + dADP = const 25 : nucleoside_diphosphate + nucleoside_triphosphate = const 26 : GMP + GDP = const 27 : GTP + guanosine_3`-diphosphate_5`-triphosphate = const 28 : RNAn + RNAn+1 = const 29 : Deoxynucleoside_triphosphate + DNAn = const 30 : Deoxynucleoside_triphosphate + DNAn+1 = const 31 : Nucleoside_triphosphate + RNAn + a_nucleoside_diphosphate = const 32 : Purine_nucleoside + phosphate + Thymidine + Nucleoside_triphosphate + RNAn + A_5`-ribonucleotide = const 33 : Purine_nucleoside + phosphate + Thymidine + Nucleoside_triphosphate + RNAn + a_ribonucleoside = const 34 : Nucleoside_2`,3`-cyclic_phosphate + nucleoside_3`-phosphate = const 35 : Nucleoside_3`,5`-cyclic_phosphate + nucleoside_5`-phosphate = const 36 : dGTP + deoxyguanosine = const 37 : dGTP + triphosphate = const 38 : Inosine + hypoxanthine = const 39 : Inosine + D-ribose = const 40 : 5-Phospho-beta-D-ribosylamine + 5-phospho-alpha-D-ribose_1-diphosphate + Adenine + Hypoxanthine + D-ribose_5-phosphate + adenine = const ELEMENTARY MODES matrix dimension r7 x c34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 34 reactions (columns) are sorted in the same order as in the ENZREV ENZIRREV section. enzymes 1: 2.1.2.2 irreversible 2: 2.1.2.3 irreversible 3: 2.4.2.1 irreversible 4: 2.4.2.4 irreversible 5: 2.7.1.25 irreversible 6: 2.7.6.1 irreversible 7: 3.1.3.5 irreversible overall reaction - not found - The remaining overall reactions perform no net transformation of external metabolites. The elementary modes ARE EQUAL to convex basis.