ID 143E_HUMAN STANDARD; PRT; 255 AA. AC P42655; P29360; Q63631; DT 01-NOV-1995 (REL. 32, CREATED) DT 01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE) DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE) DE 14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L DE SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E). GN YWHAE. OS HOMO SAPIENS (HUMAN), RATTUS NORVEGICUS (RAT), MUS MUSCULUS (MOUSE), OS BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC PRIMATES; CATARRHINI; HOMINIDAE; HOMO. RN [1] RP SEQUENCE FROM N.A. RC SPECIES=HUMAN; RX MEDLINE; 95372385. RA CONKLIN D.S., GALAKTIONOV K., BEACH D.; RT "14-3-3 proteins associate with cdc25 phosphatases."; RL PROC. NATL. ACAD. SCI. U.S.A. 92:7892-7896(1995). RN [2] RP SEQUENCE FROM N.A. RC SPECIES=HUMAN; TISSUE=HEART; RA LUK S.C.W., LEE C.Y., WAYE M.M.Y.; RL SUBMITTED (JUN-1995) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [3] RP SEQUENCE FROM N.A. RC SPECIES=HUMAN; RX MEDLINE; 96300316. RA JIN D.Y., LYU M.S., KOZAK C.A., JEANG K.T.; RT "Function of 14-3-3 proteins."; RL NATURE 382:308-308(1996). RN [4] RP SEQUENCE FROM N.A. RC SPECIES=HUMAN; TISSUE=LIVER; RX MEDLINE; 97011338. RA CHONG S.S., TANIGAMI A., ROSCHKE A.V., LEDBETTER D.H.; RT "14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on RT chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome RT region."; RL GENOME RES. 6:735-741(1996). RN [5] RP SEQUENCE FROM N.A. RC SPECIES=HUMAN; RA TANIGAMI A., CHONG S.S., LEDBETTER D.H.; RT "14-3-3 epsilon genomic sequence."; RL SUBMITTED (AUG-1998) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [6] RP SEQUENCE FROM N.A. RC SPECIES=RAT, AND SHEEP; TISSUE=PINEAL GLAND; RX MEDLINE; 94296566. RA ROSEBOOM P.H., WELLER J.L., BABILA T., AITKEN A., SELLERS L.A., RA MOFFET J.R., NAMBOODIRI M.A., KLEIN D.C.; RT "Cloning and characterization of the epsilon and zeta isoforms of the RT 14-3-3 proteins."; RL DNA CELL BIOL. 13:629-640(1994). RN [7] RP SEQUENCE FROM N.A. RC SPECIES=RAT; TISSUE=LIVER; RX MEDLINE; 95122474. RA ALAM R., HACHIYA N., SAKAGUCHI M., SHUN-ICHIRO K., IWANAGA S., RA KITAJIMA M., MIHARA K., OMURA T.; RT "cDNA cloning and characterization of mitochondrial import RT stimulation factor (MSF) purified from rat liver cytosol."; RL J. BIOCHEM. 116:416-425(1994). RN [8] RP SEQUENCE FROM N.A. RC SPECIES=RAT; TISSUE=BRAIN; RX MEDLINE; 96280718. RA GAO L., GU X.B., YU D.S., YU R.K., ZENG G.; RT "Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha 2,3- RT sialyltransferase."; RL BIOCHEM. BIOPHYS. RES. COMMUN. 224:103-107(1996). RN [9] RP SEQUENCE FROM N.A. RC SPECIES=MOUSE; STRAIN=SWISS; TISSUE=KIDNEY; RX MEDLINE; 95269876. RA MCCONNELL J.E., ARMSTRONG J.F., BARD J.B.; RT "The mouse 14-3-3 epsilon isoform, a kinase regulator whose RT expression pattern is modulated in mesenchyme and neuronal RT differentiation."; RL DEV. BIOL. 169:218-228(1995). RN [10] RP SEQUENCE FROM N.A. RC SPECIES=MOUSE; STRAIN=129/SV; RA TAKIHARA Y., IRIE K., NOMURA M., MOTALEB M., MATSUMOTO K., RA SHIMADA K.; RL SUBMITTED (SEP-1996) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [11] RP SEQUENCE FROM N.A. RC SPECIES=BOVINE; RA JONES J.M., NIIKURA T., PINKE R.M., GUO W., MOLDAY L., LEYKAM J., RA MCCONNELL D.G.; RT "Expression of 14-3-3 proteins in bovine retinal photoreceptors."; RL SUBMITTED (JAN-1998) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [12] RP SEQUENCE OF 1-152; 165-184 AND 216-255. RC SPECIES=SHEEP; TISSUE=BRAIN; RX MEDLINE; 92283271. RA TOKER A., SELLERS L.A., AMESS B., PATEL Y., HARRIS A., AITKEN A.; RT "Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) RT from sheep brain. Amino acid sequence of phosphorylated forms."; RL EUR. J. BIOCHEM. 206:453-461(1992). RN [13] RP SEQUENCE OF 1-23 AND 125-140. RC SPECIES=SHEEP; TISSUE=BRAIN; RX MEDLINE; 90345949. RA TOKER A., ELLIS C.A., SELLERS L.A., AITKEN A.; RT "Protein kinase C inhibitor proteins. Purification from sheep brain RT and sequence similarity to lipocortins and 14-3-3 protein."; RL EUR. J. BIOCHEM. 191:421-429(1990). CC -!- FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE CC PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND CC STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL CC REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH CC KINASES. CC -!- SUBUNIT: HOMODIMER. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC. CC -!- TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND CC ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO CC PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES. CC -!- SIMILARITY: BELONGS TO THE 14-3-3 FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U28936; G984319; -. DR EMBL; U20972; G902787; -. DR EMBL; U43399; G1184725; -. DR EMBL; U54778; G1561719; -. DR EMBL; AB017103; D1033501; -. DR EMBL; AB017098; D1033501; JOINED. DR EMBL; AB017099; D1033501; JOINED. DR EMBL; AB017100; D1033501; JOINED. DR EMBL; AB017101; D1033501; JOINED. DR EMBL; AB017102; D1033501; JOINED. DR EMBL; M84416; G294504; -. DR EMBL; D30739; G487918; -. DR EMBL; Z19599; G57966; -. DR EMBL; U53882; G1469948; -. DR EMBL; L07914; G530049; -. DR EMBL; D87663; G1526545; -. DR EMBL; AF043735; G3676399; -. DR PIR; S10806; S10806. DR PIR; S10807; S10807. DR MGD; MGI:894689; YWHAE. DR PROSITE; PS00796; 1433_1; 1. DR PROSITE; PS00797; 1433_2; 1. DR PFAM; PF00244; 14-3-3; 1. KW BRAIN; NEURONE; ACETYLATION; MULTIGENE FAMILY. FT MOD_RES 1 1 ACETYLATION. FT CONFLICT 73 73 K -> T (IN REF. 8). FT CONFLICT 120 120 F -> S (IN REF. 8). FT CONFLICT 123 123 K -> Y (IN REF. 8). FT CONFLICT 129 129 H -> Y (IN REF. 13). SQ SEQUENCE 255 AA; 29174 MW; 40A43E62 CRC32; MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV EDENQ //